IVC filter as adjunctive therapy in massive PE?
Background— Acute massive pulmonary embolism (PE) carries an exceptionally high mortality rate. We explored how often adjunctive therapies, particularly thrombolysis and inferior vena caval (IVC) filter placement, were performed and how these therapies affected the clinical outcome of patients with massive PE.
Patients— Among 2392 patients with acute PE and known systolic arterial blood pressure at presentation, from the International Cooperative Pulmonary Embolism Registry (ICOPER), 108 (4.5%) had massive PE, defined as a systolic arterial pressure less than 90 mm Hg, and 2284 (95.5%) had non–massive PE with a systolic arterial pressure more than/= 90 mm Hg. PE was first diagnosed at autopsy in 16 patients (15%) with massive PE and in 29 patients (1%) with non–massive PE.
massive PE vs non-massive PE
- The 90-day mortality rates were 52.4% vs 14.7%
- In-hospital bleeding complications occurred in 17.6% versus 9.7% and
- recurrent PE within 90 days in 12.6% and 7.6%
In patients with massive PE
- Thrombolytic therapy did not reduce 90-day mortality
- Recurrent PE rates at 90 days were similar in patients with and without thrombolytic therapy (12% for both)
- None of the 11 patients who received an IVC filter developed recurrent PE within 90 days, and 10 (90.9%) survived at least 90 days. IVC filters were associated with a reduction in 90-day mortality.
Conclusions— In ICOPER, two thirds of the patients with massive PE did not receive thrombolysis or embolectomy. Counterintuitively, thrombolysis did not reduce mortality or recurrent PE at 90 days. The observed reduction in mortality from IVC filters requires further investigation.
Reference: click to get abstract
Massive Pulmonary Embolism - Circulation. 2006;113:577-582.
